Dr. Reis received his medical degree in 1989, internal medicine fellowship in 1990, and cardiology fellowship in 1992. He traveled to the University of Michigan for a cardiology research fellowship from 1993 to 1994. He obtained his PhD in 2001 at Heart Institute, University of Sao Paulo.

Dr. Reis is now serving as an associate professor of medicine at the Department of Medicine, Pontifical Catholic University of Minas Gerais (PUC-Minas), since 2001. He also was a director of the PUC-Minas Medical School at Contagem, MG, Brazil (2015–2020). He built up a large cardiovascular research clinic (CARDRESEARCH) in Belo Horizonte, focusing on global health evaluation, epidemiological evaluation of cardiac risk factors, and patient-centered clinical research with emphasis on cardiovascular chronic conditions.

During the COVID-19 pandemic, he proposed the TOGETHER Trial in partnership with scientists from McMaster University and built up a large primary care clinical research frame network focusing on COVID-19 early mild disease patients.